Combination of systemic terbinafine (250 mg) twice daily and itraconazole (100 mg) twice in a pulse dose in resistant tinea infection

<p class="abstract"><strong>Background:</strong> The management of tinea is challenging in Bangladesh and there are reports using systemic antifungals at higher doses. aim the study was to find out effectiveness terbinafine (250 mg) twice daily itraconazole (100 a pulse dose resistant infection.</p><p class="abstract"><strong>Methods:</strong> It prospective, observational conducted department dermatology venereology, Dhaka Dermatology Institute, Dhaka, from November 2020 October 2021. Clinically confirmed cases corporis et cruris were recruited by random sampling techniques for followed up 12 weeks, till completion their treatment. Patients who pregnant, lactating, non-consensual, as well those had history anti-mycotic treatment within 2 weeks prior baseline visit excluded study.<strong></strong></p><p class="abstract"><strong>Results:</strong> A total 30 patients randomly assigned included study<strong>.</strong> According 4 11 (36.33%) significantly improved 19 (63.33%) non-significantly improved, >4 week 8 16 (84.21%) 3 (15.79%) >8 (100%) properly. Mycological cure achieved 25 (82.89%) patients, clinical rate same 24 (79%) complete patients.</p><p class="abstract"><strong>Conclusions:</strong> combination therapy may be an effective safe therapeutic strategy registrant infection.</p>